Spencer Knox


Dr. Spencer Knox, M.D. specializes in the diagnosis and management of a wide array of gastrointestinal diseases. Originally from upstate New York, Dr. Knox obtained a bachelor's degree with distinction in Psychology at the University of Rochester. He earned his Doctor of Medicine (M.D.) degree at the American University of the Caribbean School of Medicine, graduating as a member of the Alpha Omega Phi Honor and Service society. While attending medical school, he was on the Dean’s List for strong academic performance.

Dr. Knox completed his Internal Medicine residency training at Orlando Regional Medical Center, Orlando Health’s flagship tertiary referral center. He went on to complete a three-year clinical Gastroenterology Fellowship at the University of Massachusetts Medical School - Baystate (Springfield, MA). Dr. Knox is experienced in the medical and endoscopic management of esophageal, stomach, small intestinal, colorectal, liver, and pancreatic diseases. He is passionate about colorectal cancer screening and surveillance of precancerous colon polyps. Dr. Knox has been mentored by renowned endoscopists, with Fellowship training in both general and advanced endoscopic techniques and therapeutics.

Moreover, Dr. Spencer Knox prides himself in providing evidence-based, up-to-date medical care for patients seeking evaluation and treatment of gastroenterological disorders. These include, but are not limited to, swallowing difficulties (dysphagia), heartburn (GERD/reflux), peptic ulcer disease, pancreaticobiliary and liver disease, colorectal cancer screening, inflammatory bowel diseases (IBD) such as UC and Crohn disease, constipation, diarrhea, with a special interest in celiac disease. Dr. Knox believes medical care should be delivered in a caring and understanding bedside manner.

In his free time, Dr. Knox enjoys spending time with his wife and young son. Hobbies include spending time boating, swimming, and traveling to new places. Dr. Knox is happily accepting all new patients.

Postgraduate Education
Internal Medicine Residency Program (Orlando, Florida)
Orlando Health
Gastroenterology Fellow
University of Massachusetts Medical School-Baystate, Gastroenterology Fellowship
  • Rizwan Shahid, MD, Rohit Singhania, MBBS, MS, FACG, Kamesh Gupta, MD, Spencer C. Knox, MD. P1458 – Psoriasis Induced by Infliximab Treatment in a Young Patient With Crohn’s Disease. Program No. P1458. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.
  • Kamesh Gupta, MBBS, Rohit Singhania, MBBS, MS, FACG, Shahid Rizwan, MBBS, Spencer C. Knox, MD. P1435 – Much Ado About Nothing:  Isolated Raised ALP In IBD Patients Due to Macrocomplex. Program No. P1435. ACG 2019 Annual Scientific Meeting Abstracts. San Antonio, Texas: American College of Gastroenterology.
  • Knox, S., Madruga, M. and Carlan, S. 2017. Mechanical bowel obstruction secondary to fecal impaction with superimposed Ogilvie Syndrome. Journal of Gerontology and Geriatrics. 65, 4 (Dec. 2017), 284-286.
  • Knox, S; Madruga, M; Carlan, S. Rare Congenital Aberrant Left Superior Pulmonary Vein Discovered with Central Line Placement in a Patient with Critical Cardiorespiratory Collapse. Case Reports in Pulmonology, vol. 2017, Article ID 8728904, 3 pages, September 2017. doi:10.1155/2017/8728904.
  • Knox S, Madruga M, Carlan SJ. Utilizing Abdominal Sonography in the Diagnosis of Ascites Caused by Heart Failure: A Patient With Cirrhosis. Journal of Diagnostic Medical Sonography. First Published August 28, 2017. 2018;34(1):50-52. doi:10.1177/8756479317727504
  • Castiglia, R; Parellada, J; Knox, S. (September, 2016). Here a Clot There a Clot Everywhere a Clot, Poster presented at: Florida Chapter 2016 Associates Meeting, American College of Physicians; Orlando, FL, USA.  (Contributing author)
  • Lienhard M, Yuan Z, Knox S, Parellada J. Herpes simplex virus encephalitis. Consultant. 2016;56(9):852-853.