Dr. Nicholas Costrini
M.D., Ph.D., MBA

Gastroenterologist

Dr. Costrini is a board-certified gastroenterologist who obtained his training at leading science and medical institutions including the Medical College of Wisconsin and Washington University School of Medicine in St. Louis. He has treated thousands of grateful patients, written widely in texts, journals, and news press regarding the diagnosis and treatment of the gamut of gastrointestinal disorders. He is a recognized authority in the arena of inflammatory bowel disease. Other interests include irritable bowel syndrome, acute and chronic liver and pancreatic diseases, and gastrointestinal cancers. He loves dogs, old and new literature, classical and rock music, and sailing although he admits he is less than an expert in all these non-medical pursuits

Postgraduate Education
1969-1973
M.D. (Class President)
The Medical College of Wisconsin
1974-1975
Assistant Resident in Medicine
Washington University School of Medicine; Barnes Hospital; St. Louis, Missouri.
1975-1976
Fellow in Gastroenterology
Washington University School of Medicine
1976-1977
Chief Resident in Medicine
Washington University School of Medicine; Barnes Hospital;St. Louis, Missouri
1977-1979
Postdoctoral Fellow in Biological Chemistry and Gastrointestinal Medicine
Washington University School of Medicine
1988
Pediatric Gastroenterology Sabbatical (2 months)
Johns Hopkins University
1989
Pediatric Gastroenterology Sabbatical (2 weeks)
Tufts University Medical Center; Boston Floating/Children’s Hospital; Boston, MA
1991
Pediatric Gastroenterology Sabbatical (2 months)
Johns Hopkins University; Baltimore, MD
2013
Masters of Business Administration
University of Massachusetts
Publications

BOOKS AND BOOK CHAPTERS:

Kalkhoff, R.K.; Costrini, N.V.; Matte, M.L.; and Kim, H.J. Metabolic Modifications by the Hormones of Pregnancy. In: Early Diabetes in Early Life, Academic Press, Inc., 1975, pp. 323-331.
Manual of Medical Therapeutics. Editors: Nicholas V. Costrini and William M. Thomson; Twenty-Second Edition, 1977; Little Brown and Co., Boston.
Costrini, N.V. and Kauffman, E., General Care of the Patient. In: Manual of Medical Therapeutics; Eds.: Nicholas V. Costrini and William M. Thomson; Twenty-Second Edition, 1977; Little, Brown and Co., Boston; pp. 1-26.
Bradshaw, R.A.; Costrini, N.V.; Thomas, K.A.; and Rubin, J.R. Structure-Function Studies of Nerve Growth Factor and its Cell Surface Receptor. In: Proceedings of Frontiers of Protein Chemistry Meeting; Hawaii, 1979. Eds.: K. Yasumasa and D. Lie; Elsevier Publishing Co., Amsterdam.
Costrini, N.V. Digestive Disease Challenges for the Community Clinician. Monograph, Kalispell Regional Medical Center Press, 2018

ARTICLES IN MAJOR AND MINOR JOURNALS:

Costrini, N.V. and Kalkhoff, R.K.:  Relative Effects of Pregnancy, Estradiol and Progesterone on Plasma Insulin and Pancreatic Islet Insulin Secretion.  J. Clin. Invest.  59:992-999, 1971 (Presented in part at the Forty-Third Annual Meeting of Central Society for Clinical Research, Chicago, 1970).

Kim, H.; Kalkhoff, R.K.; Costrini, N.V.; et al:  Plasma Insulin Disturbances in Primary Hyperparathyroidism; J. Clin Invest. 50 (12);2596-2605, 1971.

Lech, J.J. and Costrini, N.V.:  In Vivo and In Vitro Metabolism of 3-Trifluoromethyl-4-Netrophenol (TFM in rainbow trout).  Comp. and General Pharm. 3:160-166, 1972.

Costrini, N.V.; Anacapa, K.P.; Whalen, G.E.; and Soergel, K.H.:  A Simple Method for Regulating and Monitoring Circulating Glucose Levels.  J. Lab. Clin. Med. 82 (1):179-186, 1973.

Costrini, N.V.; Ganeshappa, K.P.; Whalen, G.E.; and Soergel, K.H.:  Effect of Diabetes, Hyperglycemia and Hyperinsulinemia on Human Intestinal Absorption of Glucose, Electrolytes and Water.  Amer. J. Physiol.  233:181-187, 1977.

Costrini, N.V. and Bradshaw, R.A.:  Binding Characteristics and Apparent Molecular Size of the Nerve Growth Factor Receptor from Rabbit Superior Cervical Ganglia.  Proc Nat’l. Acad.  Sci.  USA 76:3242-3246, 1979.

Costrini, N.V.; Kogan, M.; Kucera, K.; and Bradshaw, R.A.: Physical Properties of the Detergent-Extracted Nerve Growth Factor Receptor of Sympathetic Ganglia.  J. boil. Chem. 254 (22):11242, 1979.

Bradshaw, R.A. and Costrini, N.V.: Nerve Growth Factor: Structure, Function and Mechanism of Action.  Japan Med. Res. Comm. 233-254, 1979.

Johnson, E.M.; Blumberg, H.M.; Costrini, N.V.; and Bradshaw, R.A.:  Reduction by Reserpine of the Accumulation of Retrogradely Transported (251 I) Nerve Growth Factor in Sympathetic Neurons, Brain Res.  178:389-401, 1979.

Costrini, N.V. and Bradshaw, R.A.:  Nerve Growth Factor.  CRC Critical Reviews in Biochemistry (invites manuscript accepted).

Costrini, N.V. and Kogan, M:  Lectin-Induced Inhibition of Nerve Growth Factor Binding by Receptors of Sympathetic Ganglia.  J. Neurochem. 36(3):1175-1180, 1981.

 Wortmann, Robert L.; Costrini, N.V.; and Adams, Nancy D.: “The Chief Medical Residency: A Description and Recommendations for Change.”  Accepted 9/81 for publication in J. Med. Educ.

Costrini, N.V. and Beck, R.:  Epidermal Growth Factor Urogastrone Receptors in Normal Human Liver and Primary Hepatoma.  Cancer.  Accepted 12/91 for publication.

Bradshaw, R.A. and Costrini, N.V.  The Structure and Function of Nerve Growth Factor in Growth and Maturation Factors.  Editor:  G. Guroff, 1983, John Wiley & Sons, Inc., pp. 1-30.

Costrini, NV. Quality of Life for Rural Georgia Colorectal Cancer Survivors. Journal of Medical Association of Georgia, J. Med. Assoc. Ga. 100 (4): 26-29,2011.  

Costrini, NV. Call Me Anything But Misguided or Thoughtless in Management of IBD. Letter to Ed. Gastro Open J. 4(1): 4-6, 2019.

Costrini, NV. What IBD Physicians Can Learn From Major League Baseball Managers. Gastro Open J. 4(1):7-8, 2019.

Costrini, NV. Clearing of the Clouds in Inflammatory Bowel Disease Management. Digestive Disease and Science, submitted and accepted 7-2020.

 

MEDICAL COLUMNS: 

For 13 years I offered a regular contributing health column for the Savannah Morning News on all topics in medicine, health care debate issues, etc. For the past year I have been a regular OPINION writer for the Gastroenterology and Endoscopy News Publication


Medical column “Good For What Ails You”, published twice monthly in The Savannah New-Press newspaper for the past 2001-2013


Medical column “Good For What Ails You”, published twice monthly in the Claxton Enterprise newspaper. 2005-2013


Medical column “Good For What Ails You”, featured in the Health Feature section on America On-Line (AOL).


Medical column published once a month in the About Savannah Magazines.


Medical column published in the Savannah Health Perspective magazine. ”The Many Faces of Crohn’s Disease”.


Gastroenterology & Endoscopy News, “ Private Practice is a Dinosaur and ACA is an Asteroid.” August , 2013.


Gastroenterology & Endoscopy News, “ MBA in Private Practice”, Jan 2014.


Gastroenterology & Endoscopy News, “ Management of Crohn’s Disease” April, 2014.


Gastroenterology and Endoscopy News, “ Standard of Care: Don’t Try This at Home “ July 2014


Daily Interlake, Health Column . “Life and Health in Montana.” Column every Other week . Began Sept. 2015

 

ABSTRACTS:

Costrini, N.V.; Jacobson, M.; and Kalhoff, R.K.:  Progesterone Augmentation of Plasma Insulin Responses and Pancreatic Islet Secretion of Insulin.  Diabetes 18 (suppl.): 322, 1969 (abstract of paper presented at Twenty-Ninth ann. Meeting of American Diabetes Association, New York, 1969)

Costrini, N.V. and Kalhoff, R.K.:  Effects of Pregnancy and Placental Steroids on Plasma Insulin Responses and Isolated Pancreatic Islet Secretion of Insulin.  Excertpa Med. 209:30, 1970 (abstract of paper presented at Seventh Congress of International Diabetes Federation, Buenos Aires, 1970).

Costrini, N.V. and Kalhoff, R.K.:  Relative Effects of Pregnancy, Estradiol and Progesterone on Plasma Insulin and Pancreatic Islet Insulin Secretion.  J. Clin. Invest. 59(5):992-999, 1971 (presented in part at the Firty-Third Annual Meeting of Central Society for Clin. Res., Chicago, 1971).

Costrini, N.V.; Whalen, G.E.; Ganeshappa, K.P.; and Soergel, K.H.:  Effect of Experimental Hyperinsulinemia on Human Intestinal Glucose, Sodium and Water Absorption.  Clin. Res. 19(3):676, 1971 (abstract of paper presented at Meeting of the Midwestern Section, Amer. Fed. for Clin. Res., Chicago, 1971).

Costrini, N.V.; Ganeshappa, K.P.; Whalen, G.E.; and Soergel, K.H.: Jejunal Glucose Absorption in Diabetes Mellitus.  Clin. Res. 20(4): 730, 1972 (presented at the meeting of the Midwestern Section of the American Fed. for Clin. Res., November 1972; and Milwaukee Research Club; Milwaukee, September 1972.

Costrini, N.V.; Whalen, G.E.; Ganeshappa, K.P. and Soergel, K.H.:  Effects of Serum Insulin and Serum Glucose Concentration on Jejunal Glucose, Sodium and Water Absorption.  Clin.  Res. 21(3): 512, 1973 (abstract submitted for presentation of paper at National Meeting of Amer. Fed. for Clin. Res.; Atlantic City; April 1973).

Costrini, N.V. and Bradshaw, R.A.:  Binding Characteristics and Apparent Molecular Size of the Nerve Growth Factor Receptor from Sympathetic Neurons.  Clin.  Res. 26:678A, 1978 (abstract of paper presented, Midwest Section, Amer. Fed. for Clin. Res., Chicago; November 2, 1978).

Costrini, N.V. and Bradshaw, R.A.: Nerve Growth Factor:  Molecular Properties of the Plasma Membrane Receptor of Rabbit Superior Cervical Ganglia.  The Endocrine Society.  Sixty-First Annual Meeting, p. 222 (presented Anaheim, California; June 14, 1979).

Costrini, N.V. and Bradshaw, R.A.:  Physical Properties of the Detergent Extracted Nerve Growth Factor Receptor.  Clin.  Res. 27(4): 654A, 1979.

Costrini, N.V. and Kogan, M.:  Glycoprotein Nature of the Nerve Growth Factor Receptor of Sympathetic Ganglia and Physical Model for Mechanism of Action (presented November 6, 1980; Meeting of the Midwestern Section of American Fed.  for Clin. Res. Chicago).  Clin. Res. 28: p. 738A, 1980.

Costrini, N.V.; Rubin, J.S.; Lieberman, M.: and Bradshaw, R.A.: Isolation and Sequence of Epidermal Growth Factor from Guinea Pig Prostate Gland.  ASBC Meeting.  St. Louis, 1981.

Wortmann, R.L.; Costrini, N.V.; and Ryan, L.M.  biological Variation of Lapin Chondrocyte 5’-Nucleotidase.  Arthritis and Rheumatism 24(4): S68, April 1968.

Costrini, N.V. and Beck, R.  Failure of Epidermal Growth Factor Antiserum to Influence Neonatal Murine Hepatic Growth.  Clin. Res., Vol. 29, No. 4, 1981, P. 712A.

Costrini, N.V. and Beck, R.  Epidermal Growth Factor Binding in Normal Liver and P primary Hepatoma Obtained from the Same Patient.  Clin. Res., Vol 29, No. 4, 1981, P. 712A.

Bradshaw, R.A., Morgan, C.J., Massaque, J., Czech, M.P., Costrini, N.V., Tait, J.F., and Weinman, S.A.  Prepared for:  International Symposium on Nervous System Regeneration; Taomina, Italy.  September 1-5, 1981.

Kruidenier, J.F., Choi, H., and Costrini, N.V.  Non-cirrhotic Portal Hypertension with Collagen Deposition in the Disse Spaces Following Glomerulonephritis.

Costrini, N.V. and Medline, T.  Pediatric Esophageal Foreign Bodies:  Analysis of 25 Consecutive Cases in Savannah, Georgia.   Prepared for:  The Third Annual Southern Pediatric Gut Club, Atlanta, Georgia, September 20-22, 1996.

Costrini, N.V. Call me anything but thoughtless or misguided in IBD management. Gastro Open J. 4 (1):4-6, 2019.

Costrini, N,V. What IBD clinicians can learn from MLB baseball. Gastro Open J. 2019.