Jose Nieto
D.O., A.G.A.F., F.A.C.P., F.A.C.G., F.A.S.G.E.

Dr. Jose Nieto
Language(s) spoken
English
Spanish

Jose M. Nieto, D.O. completed his fellowship in gastroenterology and hepatology at the University of California, Los Angeles and completed an additional year of advanced endoscopy training in interventional pancreatobiliary endoscopy and endoscopic ultrasound at UCLA Medical Center.

He joins us from Orlando, Florida, where he was on the clinical faculty staff at Florida Hospital Cancer Institute and was essential in the development of the pancreatic disease and cancer program there.

View his informational video on diverticulosis, his review of colon cancer in African Americans and how the esophageal stent fixation with endoscopic suturing device improves clinical outcomes and information on minimally invasive endoscopy

Review the case report on the procedure double endoscopic bypass for gastric outlet obstruction and biliary obstruction with Dr. Nieto and additional authors.

Videos
Postgraduate Education
2000 - 2001
Internship-Categorical Internal Medicine
University of California, Los Angeles and VA Greater Los Angeles Healthcare System
2001 - 2003
Residency, Internal Medicine
University of California, Los Angeles and VA Greater Los Angeles Healthcare System
2003
Research Fellowship, Pancreatic/Liver Diseases
University of California, Los Angeles, VA Greater Los Angeles Healthcare System
2003 - 2006
Fellowship, Gastroenterology and Hepatology
University of California, Los Angeles and Affiliated Programs
2006 -2007
Fellowship, Interventional Pancreatobiliary Endoscopy and Endoscopic Ultrasound
University of California, Los Angles, Harbor-UCLA Medical Center
2008
American Society of Bariatric Medicine - Obesity Course
2014
Olympus ESD Master Class
University of Colorado, Denver Medical Center
Publications

Siddiqui Ali , Tang Julian, Kowalski Thomas E, Loren David, Khalid Ammara, Soomro Ayesha, Mazhar Syed, Rosé Julian, Isby Laura, Kahaleh Michael, Kalra Ankush, Sarkisian Alex, Kumta Nikhil, Nieto Jose, Sharaiha Reem.
Esophageal stent fixation with endoscopic suturing device improves clinical outcomes and reduces complications in patients with locally advanced esophageal cancer prior to neoadjuvant therapy: a large multicenter experience.
Siddiqui AA, et al. Surg Endosc. August 5, 2016.

Author information
• Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA. a
• Division of Gastroenterology and Hepatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
• Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
• Division of Gastroenterology, Weill Cornell Medical School, New York, NY, USA.
• Borland Groover, Jacksonville, FL, USA.

Citation
Surg Endosc. 2016 Aug 5. [Epub ahead of print]


Tang SJ, Nieto JM, Jensen D. Ohning GV, Pisegna JR. The Novel Use of an Intravenous Proton Pump Inhibitor (Pantoprazole) in a Patient with Short Bowel Syndrome: Case Report and Literature Review. Journal of Clinical Gastroenterology. 2002 Jan; 34(1):62-63.

Saab S, DeRossa V, Nieto JM, Durazgo F, Han SH, Roth B. Costs and clinical outcomes of primary prophylaxis of variceal bleeding in patients with hepatic cirrhosis: a decision analytic model. American Journal of Gastroenterology. 2003 Apr; 98(4):763-770.

Saab S, Ly D, Nieto JM, Kanwal F, Lu D, Raman S, Amado R, Durazo F, Han S, Farmer DG, Ghobrial R, Yersiz H, Goldstein LI, Tong M, Busuttil RW.Hepatocellular Carcinoma Screening in Patients Waiting for Liver Transplantation: A Decision Analytic Model. Liver Transplantation. 2003 Jul; 9(7):672-681.

Tao N, Stussman S, Nieto JM, Tsukamoto H, Yuan JM. Demographic Characteristics of Hopitalized Patients with Alcoholic Liver Disease and Pacreatitis in Los Angeles. Alcohol Clin Exp Res. 2003 Nov;27(11):1798-1804.

Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR Jr, Shimosegawa T, Pandol SJ. PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G582-91

Nieto JM, Saab S. Transjugular Intrahepatic Portosystemic Shunt versus Medical Treatment of Refractory Ascites: A Systematic Review. Cochrane Database Syst Rev. 2004;3:CD004889.

Ibrahim AB, Shpaner A, Nieto JM, Saab S. Liver fibrosis is accelerated in HIV/HCV coinfection: a matched analysis. SA Gastroenterol 2004, 2 (3): 14-17.

Nieto JM, Pisegna JP. The Role of Proton Pump Inhibitors in the Treatment of Zollinger-Ellison Syndrome. Target Journal: Expert Opinions in Pharmacotherapy 2006 Feb;7(2):169-75.

Nieto JM, Saab S. Outcomes of Liver Transplantation using Hepatitis B core positive Liver Grafts: Implications for Prophylaxis. Textbook: Current Hepatitis Reports2006 Feb; 5: 33-39.

Saab,S, Nieto JM, Lewis K, Runyon, B. TIPS versus paracentesis for cirrhotic patients with refractory ascites. Cochrane Database Syst Rev. 2006; 4 CD004889

Nieto JM, Saab S. Outcomes of Liver Transplantation using Hepatitis B core positive Liver Grafts: 2008 Update. Textbook: Current Hepatitis Reports 2008 April; 2: 68-79.

Wang HS, Oh DS, Anderson A, Nieto J, Tien P, Ohning G, Pisegna JR. Comparative Efficacy of Rabeprazole and Pantoprazole in the Control of Nocturnal Acid Output and Intragastric Acidity. Gut Liver. 2008 Jun (2) 30-38.

Lugea A, Gong J, Nguyen J, Nieto J, French SW, Pandol SJ. Cholinergic Mediation of Alcohol-Induced Experimental Pancreatitis. Alcohol Clin Exp Res. 2010 Aug 9;170(15):1768-81

Jahng AW, Reicher S, Chung D, Varela D, Nieto J,  Pham B, Venegas RJ, French SW. Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy. World J GAstointest Endosc. 2010 Nov 16 ;2 (11):362-8

Nieto JM. Mangement of Gastroparesis. Northeast Florida Medicine 2013 Feb 64:1, 37-29.

Abstracts

Deguzman, LJ, Nieto JM. Early Viral Clearance at One Month and Three Months is Highly Predictive of Sustained Response During Induction Dose Interferon Alpha-2B Therapy for Chronic Hepatitis C (HCV) Infection. American Association for the Study of Liver Diseases Annual Meeting, November 1999, Hepatology: A401 Presidents Choice Poster Award

Nieto JM, Deguzman LJ. The Mucosal Clip Assisted Method (MCAM) for the Placement of Percutaneously Placed Jejunal Enteral Tubes (JET/PEG) is Safe and Effective. Digestive Disease Week, May 2000, Gastroenterology: A4740.

DeGuzman LJ, Nieto JM, Leckemby D, and Onuma, E. Randomized Trial Comparing the Efficacy of the Mucosal Clip Assisted Method (MCAM) vs. the Standard Pull Method (SPM) for the Placement of Percutaneously Placed Jejunal Enteral Tubes. American College of Gastroenterology, Octorber 2000, The American Journal of Gastroenterology: A282.

DeGuzman, LJ, Nieto JM, Schmidt WM. Hepatitis C Virus (HCV) RNA in Plasma and Not Peripheral Blood Mononuclear Cells (PBMC) is Comparable to Hepatic HCV RNA When Obtained While on Therapy at the End of Treatment as a Predictor of Sustained Response in Patients with Chronic Hepatitis C Infection. American Association for the Study of Liver Diseases Annual Meeting, November 2000, Hepatology: A776.

Nieto JM, Saab S. Surgical versus Medical Treatment of Refractory Ascites: A Meta-analysis of Randomized Controlled trials. American College of Physicians- Southern California Region I Meeting, February 2001, Los Angeles, CA: A10.

DeGuzman LJ, Nieto JM, DeGuzman S, Conrad A, Collins B. Plasma HCV RNA is Comparable to Hepatic HCV RNA When Obtained While on Therapy at the End of Treatment as a Predictor of Sustained Response in Patients with Chronic Hepatitis C Infection. Digestive Disease Week, May 2001, Gastroenterology: A153.

Saab S, DeRossa V, Nieto JM. Decision Analytic Model Comparing Strategies For Primary Prophylaxis Of Variceal Bleeding In Patient With Hepatic Cirrhosis. Digestive Disease Week, May 2002. Gastroenterology: A1263.

Nieto JM, DeRossa V, Deguzman LJ. Crohn’s Disease of the Vulva Antedating Gastrointestinal Involvement: Case Report. American College of Gastroenterology, Oct 2003. Seattle, WA. The American Journal of Gastroenterology: A376.

Nieto JM, Farrell J. A Novel Presentation of an Intraductal Papillary Mucinous Tumor in a Patient with Peutz-Jehger Syndrome. A Case Report: American College of Gastroenterology,Oct 2003. Seattle, WA. The American College of Gastroenterology: A384.

Saab S, DeRossa VP, Nieto JM. Cost and Clinical Outcomes of Primary Prophylaxis o Variceal Bleeding In Cirrhotics: A Decision Analytic Model. American Association for the Study of Liver Diseases Annual Meeting, November 2002, Hepatology: A1400.

Nieto JM, Saab S. Medical versus Surgical and Radiological Treatment of Refractory Ascites: A Meta-Analysis of Randomized Control Trials. American Association for the Study of Liver Diseases Annual Meeting, November 2002, Hepatology: A1465

Saab S, Ly D, Nieto JM, Kanwal F, Durazo F, Han S, Busuttil R. Hepatocellular Carcinoma Surveillance in Patients Awaiting Liver Transplantation Can Be Cost-Effective. American Association for the Study of Liver Diseases Annual Meeting, November 2002, Hepatology: A2218.

Satoh A, Gukovskaya A, Nieto JM, Lee O, Cheng JH, Nam KJ, Reeve JR, Pandol SJ. Activation of individual protein kinase C isoforms and their role in CCK- induced NF-κB activation in pancreatic acinar cells. Digestive Disease Week, May 2003. Gastroenterology: A1456.

Wolf C, Nieto JM, Ibrahimi J. Prophylactic Mucomyst versus Placebo for the Prevention of Contrast Induced Nephropathy During Cardiac Catherization: A Meta-analysis. American Cardiology Association, November 2003.

Lugea A, Nieto JM, Gukovsky I, Satoh A, Pandol, S. J. Role of the Cholinegic System in Alcohol-Induced Pancreatitis. American Pancreatic Association,, November 2003. Pancreas: 33: (4) 479-480.

Hernandez JC, Tsai F, Chung D, Nieto JM, French S, Eysselein VE. Frequency of Buried Barrett’s Metaplasia After BARRX Ablation for Intestinal Metaplasia with Or Without Dysplasia. Digestive Disease Week, April 2007, Gastrointestinal Endoscopy: AB111

Nieto JM, Alia D, Reicher S, Chung D, Pham BV, French S, Stabile B, Eysselein VE. Immunohistochemical Staining Improves the Diagnostic Yield of Endoscopic Ultrasonography Guided Fine Needle Aspirates of Pancreatic Solid Lesions. Digestive Disease Week, April 2007, Gastrointestinal Endoscopy: T1582

Shah R, Shah JN,  Waxman I, Kowalski t, Sanchez-Yague A, Nieto J, Brauer B, Gaidhane M, Kahaleh M. EUS-Guided Drainage of Pancreatic Pseudocysts (PP) Utilizing a Novel Anchoring, Covered Self-Expanding Metal Sent (Acsems): Results Froma Prospective, Multi-Center Study.  Digestive Disease Week, May 2013. Gastrointestinal Endoscopy:,  AB128

RESEARCH EXPERIENCE

1992-1996 Localization and Effects of Alcohol Dehydrogenase Activity at the Neuromuscular Junction

University of California, Los Angeles

Department of Neurophysiology

Principal Investigator: Michael S. Letinsky, Ph.D.

 

1997-2001 Hepatitis C Clinical Research

Arrowhead Regional Medical Center, Western University of Health Sciences

Co-Investigator, Department of Gastroenterology and Hepatology

Principal Investigator: Lino Deguzman, M.D.

 

2003- 2004 Pancreatology Research

University of California, Los Angeles, Greater Los Angeles VA Medical Center

Co-Investigator, Pancreatic Research Center

Principal Investigator: S Pandol, M.D.

 

2000- 2007 Hepatology and Gastroenterology Research

University of California, Los Angeles, Center of Health Sciences

Co-Investigator, Division of Liver and Digestive Diseases

Principal Investigator: S. Saab, MPH, M.D.

 

2007-2010 Gastroenterology Research

Principle Investigator, Barretts’ Esophagus Registry

 

2011-Current Gastroenterology and Hepatology Research

Investigator: Borland Groover Research Department

 

 

PRINCIPAL SITE INVESTIGATOR

2012 EUS-Guided Drainage of Pancreatic Pseudocysts (PP) Utilizing a Novel Anchoring, Covered Self-Expanding Metal Sent (Acsems): Results From a Prospective, Multi-Center Study

 

2012 A Prospective Evaluation of a Novel Device for EUS guided Fiducial Placement for Stereotatic Body Radiotherapy

 

2013 A Randomized, Double-Blind, Vehicle-Controlled, Multicenter Study to Evaluate Safety and Efficacy of Investigation Product, 25 mg Rectal Suppositories in the Treatment of Symptomatic Internal Hemorrhoids

 

2013 A Randomized, Double-Blind Placebo Controlled, Multicenter Study for 26 Week Efficacy and Safety for Patients with Chronic Idiopathic Constipation (ECHO 1)

 

2014 TruFreeze Spray Cryotherapy Patient Registry

 

2014 Beacon Comparative effectiveness of fixed-number versus cytopathologist/cytotechnologist-guided endoscopic ultrasound guided fine needle aspiration of pancreatic solid masses

 

2014 Palliation of Biliary Neoplasm’s with the Cook Evolution® Biliary Stent System

 

2014 CP201303- AXIOS Stent with Electrocautery Enhanced Delivery System

 

2015 MUSE Medigus Ultrasonic Surgical StaplerSystem Patient Registry

 

2015 Palliation of Biliary Neoplasm’s with the Cook Evolution® Biliary Fully Covered Stent System

 

2015 Evaluation of the Effectiveness of Evolution® Biliary Stent System – Fully Covered

 

2015 Comparative effectiveness of fixed-number versus

cytopathologist/cytotechnologist-guided and 2 different needles in endoscopic ultrasound guided fine needle aspiration of pancreatic solid masses

 

SUB INVESTIGATOR:

2014 Alvine ALV003-1221 A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Dose- Ranging Study of the Efficacy and Safety of ALV003 Treatment in Symptomatic Celiac Disease Patients Maintained on a Gluten-Free Diet

 

2014 AbbVie: M14-222 An Open-Label, Multicenter Study to Evaluate Long-term Outcomes with ABT-450/Ritonavir/ABT-267 (ABT-450/r/ ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection (TOPAZ II)

 

2014 Gilead GS-US-342-1138 A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sofosbuvir/GS-5816 Fixed Dose Combination for 12 Weeks in Subjects with Chronic HCV.

 

2014 Gilead GS-US-342-1139 A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Sofosbuvir/GS-5816 Fixed Dose Combination for 12 Weeks with Sofosbuvir and Ribavirin for 12 Weeks in Subjects with Chronic Genotype 2 HCV Infection

 

2014 Gilead GS-US-342-1140 A Phase 3, Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Sofosbuvir/GS-5816 Fixed Dose Combination for 12 Weeks with Sofosbuvir and Ribavirin for 24 Weeks in Subjects with Chronic Genotype 3 HCV Infection

 

2014 Gilead GS-US-342-1553 An Open Label Study to Evaluate The Efficacy And Safety Of Sofosbuvir/GS-5816 Fixed Dose Combination With Ribavirin For 24 Weeks In Chronic HCV Infected Subjects Who Participated In A Prior Gilead Sponsored HCV Treatment Study

 

2014 Janssen TMC435HPC3017 A Phase 3, Multicenter, Randomized, Open-Label Study to Investigate the Efficacy and Safety of a 12- or 8-Week Treatment Regimen of Simeprevir in Combination with Sofosbuvir in Treatment-Naïve and -Experienced Subjects with Chronic Genotype 1 Hepatitis C Virus Infection Without Cirrhosis

 

2015 Gilead GS-US-337-1431 A Registry for Subjects with Cirrhosis Who Achieve Sustained Virologic Response Following Treatment with a Sofosbuvir-Based Regimen without Interferon for Chronic Hepatitis C Infection in Gilead-Sponsored Trials

 

2015 AbbVie: M15-410 A Randomized, Open-Label, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-Administration of ABT-493 and ABT-530 With and Without Ribavirin in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection who Failed a Prior Direct-Acting Antiviral Agent (DAA)-Containing Therapy

 

2015 Gilead GS-US-248-0122 A Long Term Follow-up Registry for Subjects Who Achieve a Sustained Virologic Response to Treatment in Gilead-Sponsored Trials in Subjects with Chronic Hepatitis C Infection

 

2015 Gilead GS-US-248-0123 A Long Term Follow-up Registry Study of Subjects Who Did Not Achieve Sustained Virologic Response In Gilead-Sponsored Trials In Subjects With Chronic Hepatitis C Infection

 

2015 Gilead GS-US-367-1168 A Phase 2, Global, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of GS-9857 Plus Sofosbuvir/GS-5816 Fixed Dose Combination in Subjects with Chronic Genotype 1 HCV Infection

 

2015 Gilead GS-US-367-1169 A Phase 2, Global, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of GS-9857 Plus Sofosbuvir/GS-5816 Fixed Dose Combination in Subjects with Chronic Non-Genotype 1 HCV Infection.

 

2016 Novartis CLJN452A2202 A Randomized, Global, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Once-daily Oral Avatrombopag for the Treatment of Adults with Thrombocytopenia Associated with Liver Disease Prior to an Elective Procedure

 

2016 Eisai E5501-G000-30 A Randomized, Global, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Once-daily Oral Avatrombopag for the Treatment of Adults with Thrombocytopenia Associated with Liver Disease Prior to an Elective Procedure

 

2016 John Hopkins Esophageal stent migration with endoscopic suture fixation compared to standard deployment in the management of benign esophageal pathology: A randomized controlled trial